CARM1 degrader-1 (hydrochloride)

Product Description: CARM1 degrader-1 hydrochloride is the hydrochloride salt form of CARM1 degrader-1 (HY-156152). CARM1 degrader-1 hydrochloride is a PROTAC degrader for co-activator associated argininemethyltransferase 1 (CARM1), which degrades CARM1 in a VHL- and proteasome-dependent manner with a DC50 of 8.1 nM. CARM1 degrader-1 hydrochloride inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, and thus inhibits breast cancer cell migration[1].

Formula: C71H99ClN12O8S

References: [1]Xie H, et al., Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders. J Med Chem. 2023 Sep 28;66(18):13028-13042.

Molecular Weight: 1316.14

Compound Purity: 99.44

Research Area: Cancer

Target: Histone Methyltransferase;PROTACs

• Artikelnummer: MEXHY-156152A-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-156152A-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK