CHM-1, CAS 154554-41-3

Product Description: CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity[1][2][3].

Applications: Cancer-Kinase/protease

Formula: C16H10FNO3

References: [1]Wang SW, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008 Feb;7(2):350-60./[2]Liu CW, et al. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. Chem Biol Interact. 2018 Jun 1;289:98-108./[3]Tsai AC, et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 2010 Feb 19;285(8):5497-506.

CAS Number: 154554-41-3

Molecular Weight: 283.25

Compound Purity: 99.57

Research Area: Cancer

Solubility: DMSO : 5 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Microtubule/Tubulin

• Artikelnummer: MEXHY-103257-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-103257-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK