Cort108297, CAS 1018679-79-2

Product Description: Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM.

Applications: Metabolism-sugar/lipid metabolism

Formula: C26H25F4N3O3S

References: [1]Sindelar DK, et al. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348(1):192-201./[2]Kach J, et al. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 Aug;16(8):1680-1692./[3]Asagami T, et al. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389./[4]Solomon MB, et al. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65(4):363-71.

CAS Number: 1018679-79-2

Molecular Weight: 535.55

Compound Purity: 99.44

Research Area: Metabolic Disease; Endocrinology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Glucocorticoid Receptor

• Artikelnummer: MEXHY-15710-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15710-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK