CPS-11, CAS 145945-21-7

Product Description: CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

Applications: Cancer-programmed cell death

Formula: C14H12N2O5

References: [1]Aragon-Ching JB, et al. Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov. 2007 Jun;2(2):167-74. /[2]Warfel NA, et al. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3502-9./[3]Ge Y, et al. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108(13):4126-35.

CAS Number: 145945-21-7

Molecular Weight: 288.26

Compound Purity: 99.39

Research Area: Cancer

Solubility: DMSO : 57.7 mg/mL (ultrasonic;warming)

Target: NF-κB;Nuclear Factor of activated T Cells (NFAT);Reactive Oxygen Species

• Artikelnummer: MEXHY-117987-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-117987-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK