Dehydronitrosonisoldipine, CAS 87375-91-5

Product Description: Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders[1].

Formula: C20H22N2O5

References: [1]Li WH, et al. Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate. Elife. 2021 May 4;10:e67381./[2]Baranda AB, et al. Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples. Forensic Sci Int. 2006 Jan 6;156(1):23-34.

CAS Number: 87375-91-5

Molecular Weight: 370.40

Compound Purity: 98.0

Research Area: Others

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Calcium Channel

• Artikelnummer: MEXHY-Z0816-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-Z0816-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK