DW18134, CAS 2626988-87-0

Product Description: DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function [1].

Formula: C24H21N5O3

References: [1]Huang Y, et al., A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease. Molecules. 2024 Apr 16;29(8):1803.

CAS Number: 2626988-87-0

Molecular Weight: 427.46

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: IRAK

• Artikelnummer: MEXHY-161620-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161620-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK