(E)-SIS3, CAS 521984-48-5

Description: (E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

CAS Number: 521984-48-5

Formula: C28H27N3O3·HCl

Molecular Weight: 489,99

References: Jinnin M, et al. Mol Pharmacol. 2006, 69(2):597-607.

• Artikelnummer: TGMT3636-1mg
• Hersteller: TargetMol Chemicals
• Hersteller Artikelnummer: T3636-1mg
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK