E6446, CAS 1219925-73-1

Product Description: E6446 is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 also improves liver pathology in high-fat diet (HFD)-fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD)[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C27H35N3O3

Citations: Infect Immun. 2019 Dec 17;88(1):e00697-19./Oxid Med Cell Longev. 2019 Apr 28;2019:6527638. /Cell Commun Signal. 2023 Sep 30;21(1):268./Patent. US20210388060A1./Research Square Preprint. 2021 Mar./Vet Microbiol. 2017 Aug;207:56-62.

References: [1]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40./[2]Franklin BS, et al. Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3689-94./[3]Wang W, et al. Identification of novel SCD1 inhibitor alleviates nonalcoholic fatty liver disease: critical role of liver-adipose axis. Cell Commun Signal. 2023 Sep 30;21(1):268.

CAS Number: 1219925-73-1

Molecular Weight: 449.59

Compound Purity: 98.0

Research Area: Metabolic Disease; Inflammation/Immunology

Solubility: DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Stearoyl-CoA Desaturase (SCD);Toll-like Receptor (TLR)

• Artikelnummer: MEXHY-12756-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12756-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK