Elobixibat, CAS 439087-18-0

Product Description: Elobixibat (A 3309; AZD 7806) is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor, with an IC50 value of 0.53 nM (human IBAT ), 0.13 nM (mouse IBAT), 5.8 nM (canine IBAT). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C36H45N3O7S2

References: [1]Sugiyama Y, et al. Impact of elobixibat on liver tumors, microbiome, and bile acid levels in a mouse model of nonalcoholic steatohepatitis. Hepatol Int. 2023 Dec;17(6):1378-1392. /[2]Yamauchi R, et al. Elobixibat, an ileal bile acid transporter inhibitor, ameliorates non-alcoholic steatohepatitis in mice. Hepatol Int. 2021 Apr;15(2):392-404. /[3]Wong BS, et al. Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb; 22(2):277-84.

CAS Number: 439087-18-0

Molecular Weight: 695.89

Compound Purity: 99.91

Research Area: Metabolic Disease; Inflammation/Immunology

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Apical Sodium-Dependent Bile Acid Transporter;Interleukin Related;TNF Receptor

• Artikelnummer: MEXHY-15790-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15790-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK