Product Description: EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2]
Applications: Cancer-programmed cell death
Formula: C13H11FN2O5S
References: [1]Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023./[2]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110.
CAS Number: 2803819-61-4
Molecular Weight: 326.30
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Others