ERK2/p38α MAPK-IN-1, CAS 1016427-72-7

Product Description: ERK2/p38α MAPK-IN-1 (Compound 1, In silico Hit-2) is a potent and selective ERK2 and p38α MAPK inhibitor, with an IC50 of 82 μM for ERK2. ERK2/p38α MAPK-IN-1 binds to the allosteric site of ERK2 and p38α MAPK in distinct manners. ERK2/p38α MAPK-IN-1 can be used for the research of type 2 diabetes[1].

Formula: C20H16FN3O4S2

References: [1]Hasegawa S, et al. Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivity. Biochem Biophys Res Commun. 2024 Apr 16;704:149707./[2]Kinoshita T, et al. Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay. Bioorg Med Chem Lett. 2016 Feb 1;26(3):955-958.

CAS Number: 1016427-72-7

Molecular Weight: 445.49

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ERK;p38 MAPK

• Artikelnummer: MEXHY-161462-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161462-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK