Furamidine (dihydrochloride), CAS 55368-40-6

Product Description: Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C18H18Cl2N4O

References: [1]Yan L, et al. Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J Med Chem. 2014 Mar 27;57(6):2611-22./[2]Antony S, et al. Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic Acids Res. 2007;35(13):4474-84./[3]Keil A, et al. The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.

CAS Number: 55368-40-6

Molecular Weight: 377.27

Compound Purity: 99.0

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: DMSO : 12.5 mg/mL (ultrasonic)

Target: Histone Methyltransferase;Parasite;Phosphodiesterase (PDE)

• Artikelnummer: MEXHY-110137-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-110137-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK