Gal-ARV-771

Product Description: Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells[1].

Formula: C71H84ClN9O19S2

References: [1]Chang M, et al. Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs. J Med Chem. 2024 May 9;67(9):7301-7311.

Molecular Weight: 1467.06

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Epigenetic Reader Domain;PROTACs

• Artikelnummer: MEXHY-158331-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158331-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK