GZNL-P36

Product Description: GZNL-P36 is an orally active inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 6.45 nM. GZNL-P36 inhibits SARS-CoV and its variants with EC50 range from 58.2 nM to 2.66 μM. GZNL-P36 exhibits a peak plasma concentration Cmax of 549 ng/mL, a half-life T1/2 of 1.45 h and a bioavailability of 74.7% in CD-1 mouse. GZNL-P36 exhibits antiviral activity in SARS-CoV-2 XXB.1 infection in mouse[1].

Formula: C29H30N4O2

References: [1]Lu Y, et al., Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19[J]. bioRxiv, 2024: 2024.04. 03.587743.

Molecular Weight: 466.57

Research Area: Infection

Solubility: 10 mM in DMSO

Target: SARS-CoV;Virus Protease

• Artikelnummer: MEXHY-162484-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-162484-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK