HA-1004 (hydrochloride), CAS 92564-34-6

Product Description: HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models[1][2][3][4].

Formula: C12H16ClN5O2S

References: [1]Almela P, et al. Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal. Front Pharmacol. 2013 Dec 27;4:164./[2]Goodman HM, et al. The isoquinoline sulfonamide inhibitors of protein phosphorylation, H-7, H-8, and HA-1004, also inhibit RNA synthesis: studies on responses of adipose tissue to growth hormone. Endocrinology. 1990 Jan;126(1):441-50./[3]Ishikawa T, et al. Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase. J Pharmacol Exp Ther. 1985 Nov;235(2):495-9./[4]Ishikawa T, et al., Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase. J Pharmacol Exp Ther. 1985 Nov;235(2):495-9.

CAS Number: 92564-34-6

Molecular Weight: 329.81

Research Area: Metabolic Disease; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Calcium Channel;Cyclic GMP-AMP Synthase;ERK;PKA;Tyrosine Hydroxylase

• Artikelnummer: MEXHY-112348-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-112348-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK