hAChE/hBACE-1-IN-4, CAS 229476-71-5

Product Description: hAChE/hBACE-1-IN-4 (compound AK-2) is a quinazoline derivative. hAChE/hBACE-1-IN-4 shows significant inhibitory activity against hAChE and hBACE-1 enzymes (hAChE, IC50=0.283 μM; hBACE-1, IC50=0.231 μM). hAChE/hBACE-1-IN-4 has the potential to inhibit Aβ aggregation. hAChE/hBACE-1-IN-4 has non-neurotoxicity , blood-brain barrier permeability and oral activity. hAChE/hBACE-1-IN-4 can be used in Alzheimer's disease research[1].

Applications: Neuroscience-Neurodegeneration

Formula: C21H24N4O2

References: [1]Verma A, Waiker D K, Singh N, et al. Lead optimization based design, synthesis, and pharmacological evaluation of quinazoline derivatives as multi-targeting agents for Alzheimer’s disease treatment[J]. European Journal of Medicinal Chemistry, 2024: 116450.

CAS Number: 229476-71-5

Molecular Weight: 364.44

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Amyloid-β;Cholinesterase (ChE)

• Artikelnummer: MEXHY-161512-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161512-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK