IAG933

Product Description: IAG933 is a small molecule compound. IAG933 is a direct and selective disruptor of YAP-TEAD protein-protein interaction (PPI). By binding to the Ω-loop pocket of TEAD protein, IAG933 directly prevents YAP/TAZ from forming complexes with TEADs, thereby interfering with YAP's carcinogenic function. IAG933 can be used to study the Hippo signaling pathway and specific types of cancer[1].

Applications: Cancer-programmed cell death

Formula: C27H26ClF2N3O4

References: [1]Chapeau EA, et al. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer. 2024 Apr 2.

Molecular Weight: 529.96

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: YAP

• Artikelnummer: MEXHY-158384-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158384-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK