ICI-63197, CAS 27277-00-5

Product Description: ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C9H13N5O

References: [1]M Hoey, et al. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem Pharmacol. 1990 Jul 15;40(2):193-202. /[2]H Wachtel. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology. 1983 Mar;22(3):267-72./[3]H Johnston, et al. Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alpha-adrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol. 1986 Mar;87(3):553-62.

CAS Number: 27277-00-5

Molecular Weight: 207.23

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Phosphodiesterase (PDE)

• Artikelnummer: MEXHY-103024-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-103024-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK