Idelalisib, CAS 870281-82-6

Product Description: Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes.

Applications: Cancer-Kinase/protease

Formula: C22H18FN7O

References: [1]Lannutti BJ, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood, 2011, 117(2), 591-594./[2]Low PC, et al. PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nat Commun. 2014 Mar 14;5:3450./[3]Herman SE, et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood, 2010, 116(12), 2078-2088./[4]Cooney J, et al. Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B cell malignancies. Clin Cancer Res. 2018 Mar 1;24(5):1103-1113.

CAS Number: 870281-82-6

Molecular Weight: 415.42

Compound Purity: 99.78

Research Area: Cancer

Solubility: DMSO : ≥ 59.7 mg/mL

Target: Autophagy;PI3K

• Artikelnummer: MEXHY-13026-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13026-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK