Description: Imidazole ketone erastin (IKE) is an iron death inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and lipid peroxidation.
CAS Number: 1801530-11-9
Formula: C35H35ClN6O5
Molecular Weight: 655,14
References: Larraufie MH, et al. Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4787-4792.