(-)-Indolactam V, CAS 90365-57-4

Product Description: (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

Applications: Cancer-Kinase/protease

Formula: C17H23N3O2

References: [1]Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61(8):1415-7./[2]Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7./[3]Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.

CAS Number: 90365-57-4

Molecular Weight: 301.38

Compound Purity: 99.30

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: PKC

• Artikelnummer: MEXHY-12307-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12307-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK