Indotecan, CAS 915303-09-2

Product Description: Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C26H26N2O7

References: [1]Balaña-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70./[2]Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.

CAS Number: 915303-09-2

Molecular Weight: 478.49

Compound Purity: 98.0

Research Area: Cancer; Infection

Solubility: DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Topoisomerase

• Artikelnummer: MEXHY-18351-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18351-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK