Product Description: JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect[1].
Formula: C71H108N28O12
References: [1]Ericson MD, et al. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]. ACS Pharmacol Transl Sci. 2024 Apr 2;7(4):1114-1125.