JTT-654, CAS 916828-66-5

Product Description: JTT-654 is an orally active, potent and selective11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. The IC50 of JTT-654 for 11β-HSD1 is 4.65, 0.97, and 0.74 nM in human, rat, and mouse recombinant enzymes, respectively. JTT-654 showed competitive inhibition against human recombinant enzyme. The IC50 value for human 11β-HSD2 is > 30 μM (human 11β-HSD2 is responsible for the reverse reaction against human 11β-HSD1). JTT-654 ameliorates insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11β-HSD1[1][2].

Formula: C28H33F3N4O3

References: [1]Heitaku S, et al. An 11-Beta Hydroxysteroid Dehydrogenase Type 1 Inhibitor, JTT-654 Ameliorates Insulin Resistance and Non-obese Type 2 Diabetes. Biol Pharm Bull. 2023;46(7):969-978./[2]Heitaku S, et al. JTT-654, an 11-beta hydroxysteroid dehydrogenase type 1 inhibitor, improves hypertension and diabetic kidney injury by suppressing angiotensinogen production. J Pharmacol Sci. 2024 Apr;154(4):246-255.

CAS Number: 916828-66-5

Molecular Weight: 530.58

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: 11β-HSD

• Artikelnummer: MEXHY-161449-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161449-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK