Kartogenin (sodium), CAS 1401168-39-5

Product Description: Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC50: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research[1][2][3][4].

Applications: COVID-19-immunoregulation

Formula: C20H14NNaO3

References: [1]Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39(1): 16-20./[2]Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2(1): 1-10./[3]Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336(6082):717-21./[4]Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10(1):201.

CAS Number: 1401168-39-5

Molecular Weight: 339.32

Compound Purity: 98.25

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: TGF-beta/Smad

• Artikelnummer: MEXHY-16268A-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16268A-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK