KT-333 (ammonium), CAS 2839758-34-6

Product Description: KT-333 ammonium (Compound A) is a molecular glues that degrades STAT3 protein. KT-333 ammonium mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL). KT-333 ammonium has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 ammonium can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL)[1].

Applications: Cancer-Kinase/protease

Formula: C60H77ClN11O14PS

References: [1]Ding X, et al. Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells. Oncotarget. 2016 Apr 12;7(15):20080-92.

CAS Number: 2839758-34-6

Molecular Weight: 1274.81

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Molecular Glues;STAT

• Artikelnummer: MEXHY-156730A-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-156730A-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK