L189, CAS 64232-83-3

Product Description: L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].

Applications: Cancer-programmed cell death

Formula: C11H10N4OS

References: [1]Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008/[2]Devashree Jahagirdar, et al. Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa. Current Cancer Therapy Reviews, 2018, 14, 1-11.

CAS Number: 64232-83-3

Molecular Weight: 246.29

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : ≥ 33 mg/mL

Target: DNA/RNA Synthesis

• Artikelnummer: MEXHY-15588-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15588-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK