Ladostigil (hemitartrate), CAS 209394-46-7

Product Description: Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease[1][2]. Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Neuroscience-Neurodegeneration

Formula: C16H20N2O2.1/2C4H6O6

References: [1]Denya I, et, al. Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease. Medchemcomm. 2018 Jan 16;9(2):357-370. /[2]Weinreb O, et, al. Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94./[3]Weinstock M, et, al. Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression. J Neural Transm Suppl. 2006;(70):443-6./[4]Poltyrev T, et, al. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats. Psychopharmacology (Berl). 2005 Aug;181(1):118-25.

CAS Number: 209394-46-7

Molecular Weight: 694.77

Compound Purity: 98.90

Research Area: Neurological Disease

Solubility: H2O : 60 mg/mL (ultrasonic;warming)/DMSO : 50 mg/mL (ultrasonic)

Target: Cholinesterase (ChE);Monoamine Oxidase

• Artikelnummer: MEXHY-10400-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10400-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK