LASSBio-1135, CAS 852453-71-5

Product Description: LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC50 = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem[1].

Formula: C18H14N4

References: [1]Lacerda RB, et al. Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes. Bioorg Med Chem. 2009 Jan 1;17(1):74-84./[2]Lima CK, et al. LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. PLoS One. 2014 Jun 18;9(6):e99510.

CAS Number: 852453-71-5

Molecular Weight: 286.33

Research Area: Inflammation/Immunology; Neurological Disease

Solubility: 10 mM in DMSO

Target: TRP Channel

• Artikelnummer: MEXHY-131986-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-131986-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK