Lenalidomide-Br, CAS 2093387-36-9

Product Description: Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].

Applications: Cancer-programmed cell death

Formula: C13H11BrN2O3

References: [1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17./[2]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

CAS Number: 2093387-36-9

Molecular Weight: 323.14

Compound Purity: 99.86

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Ligands for E3 Ligase

• Artikelnummer: MEXHY-43722-1G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-43722-1G
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK