Product Description: Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609)[1].
Applications: Cancer-programmed cell death
Formula: C13H11IN2O3
References: [1]Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
CAS Number: 2207541-30-6
Molecular Weight: 370.14
Compound Purity: 99.90
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Ligands for E3 Ligase