Lifitegrast (sodium), CAS 1119276-80-0

Product Description: Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease[1].

Applications: COVID-19-immunoregulation

Formula: C29H23Cl2N2NaO7S

References: [1]Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15./[2]Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402./[3]Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin(STZ) model of diabetic retinopathy (DR). Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204.

CAS Number: 1119276-80-0

Molecular Weight: 637.46

Compound Purity: 99.33

Research Area: Inflammation/Immunology

Target: Integrin

• Artikelnummer: MEXHY-19344A-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19344A-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK