Lonidamine (Standard), CAS 50264-69-2

Product Description: Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3].

Formula: N/A

References: [1]Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36. /[2]Ilya A Shutkov, et al. Ru(III) Complexes with Lonidamine-Modified Ligands. Int J Mol Sci. 2021 Dec 15;22(24):13468. /[3]Xueqian Yin, et al. Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β. Sci Signal. 2019 Dec 17;12(612):eaax4067. /[4]Gang Cheng, et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019 May 17;10(1):2205.

CAS Number: 50264-69-2

Molecular Weight: N/A

Research Area: Cancer; Inflammation/Immunology

Target: Apoptosis;Hexokinase;Mitochondrial Metabolism;Parasite

• Artikelnummer: MEXHY-B0486R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0486R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK