LRRK2-IN-14, CAS 2942328-06-3

Product Description: LRRK2-IN-14 (Compound 8) is an orally active LRRK2 inhibitor. LRRK2-IN-14 has an IC50 of 6.3 nM for LRRK2(G2019S) cell activity.LRRK2-IN-14 has an inhibitory effect on hERG (IC50=22 μM). LRRK2-IN-14 has blood-brain barrier permeability[1].

Formula: C17H18F3N5O2

References: [1]Kim K, et al. Concurrent Optimizations of Efficacy and Blood-Brain Barrier Permeability in New Macrocyclic LRRK2 Inhibitors for Potential Parkinson's Disease Therapeutics. J Med Chem. 2024 May 9;67(9):7647-7662.

CAS Number: 2942328-06-3

Molecular Weight: 381.35

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: LRRK2

• Artikelnummer: MEXHY-158365-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158365-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK