Mibefradil (dihydrochloride), CAS 116666-63-8

Product Description: Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively)[1].

Applications: COVID-19-immunoregulation

Formula: C29H40Cl2FN3O3

Citations: Front Pharmacol. 2022 Feb 23;13:816133./PLoS Biol. 2024 Mar 25;22(3):e3002565./Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868./Br J Pharmacol. 2021 Jan;178(2):346-362./Eur J Pharmacol. 2021 Feb 5;892:173782./Front Pharmacol. 23 February 2022./J Cell Physiol. 2021 Mar 11./Mediat Inflamm. 2020 Nov 10;2020:3691701./Theriogenology. 2021 Jan 1;159:140-146.

References: [1]Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8./[2]Yu YF, et al. Protection of the cochlear hair cells in adult C57BL/6J mice by T-type calcium channel blockers. Exp Ther Med. 2016 Mar;11(3):1039-1044./[3]Shiue SJ, et al. Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats. Acta Anaesthesiol Taiwan. 2016 Oct 17. pii: S1875-4597(16)30071-6./[4]Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35.

CAS Number: 116666-63-8

Molecular Weight: 568.55

Compound Purity: 98.85

Research Area: Cardiovascular Disease; Cancer

Solubility: H2O : 150 mg/mL (ultrasonic)

Target: Calcium Channel

• Artikelnummer: MEXHY-15553A-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15553A-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK