MK-0752, CAS 471905-41-6

Product Description: MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo[1][2].

Applications: Cancer-programmed cell death

Formula: C21H21ClF2O4S

References: [1]Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750./[2]Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313.

CAS Number: 471905-41-6

Molecular Weight: 442.90

Compound Purity: 99.35

Research Area: Neurological Disease; Cancer

Solubility: DMSO : ≥ 100 mg/mL/Ethanol : 10 mg/mL (ultrasonic)

Target: γ-secretase

• Artikelnummer: MEXHY-10974-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10974-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK