(±)-ML 209, CAS 1334526-14-5

Product Description: (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells[1].

Applications: COVID-19-immunoregulation

Formula: C25H31NO6

References: [1]Jun R Huh, et al. Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett. 2013 Jan 10;4(1):79-84.

CAS Number: 1334526-14-5

Molecular Weight: 441.52

Compound Purity: 99.87

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: ROR

• Artikelnummer: MEXHY-126037-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-126037-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK