Product Description: MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2].
Applications: Cancer-Kinase/protease
Formula: C24H25F3N6S
References: [1]Duffey MO, et al. Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem. 2012 Jan 12;55(1):197-208./[2]Shi JQ, et al. MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. Mol Cancer Ther. 2012 Sep;11(9):2045-53.
CAS Number: 1228960-69-7
Molecular Weight: 486.56
Compound Purity: 99.94
Research Area: Cancer
Solubility: DMSO : ≥ 30 mg/mL
Target: Polo-like Kinase (PLK)