Product Description: MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s)[1].
Formula: C20H9F5N4
References: [1]Atack JR. GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics. Curr Top Med Chem. 2011;11(9):1176-202.
CAS Number: 461450-30-6
Molecular Weight: 400.30
Compound Purity: 99.31
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: GABA Receptor