MS181

Product Description: MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. MS181 decreases the expression of EED, EZH2, SUZ12, BMI1 and RING1B. MS181 shows antiproliferative activity (Strtucture Note: Red, EED binder (HY-158771); Blue, CRBN ligand (HY-41547); Black, Linker HY-131717)[1].

Formula: C39H41N11O6

References: [1]Kabir M, et al. Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. J Med Chem. 2024 Apr 25;67(8):6880-6892.

Molecular Weight: 759.81

Research Area: Cancer

Target: E1/E2/E3 Enzyme;PROTACs

• Artikelnummer: MEXHY-158239-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158239-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK