nAChR agonist 1, CAS 1394371-75-5

Product Description: nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease[1].

Applications: Neuroscience-Neurodegeneration

Formula: C20H18ClNO3S2

References: [1]Sinha N, et al.Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization. J Med Chem. 2020 Feb 13;63(3):944-960.

CAS Number: 1394371-75-5

Molecular Weight: 419.94

Compound Purity: 98.35

Research Area: Neurological Disease

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: nAChR

• Artikelnummer: MEXHY-133011-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-133011-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK