Nitracrine, CAS 4533-39-5

Product Description: Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells[1][2][3].

Applications: Cancer-programmed cell death

Formula: C18H20N4O2

References: [1]Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49(2):215-23./[2]Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81./[3]Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32.

CAS Number: 4533-39-5

Molecular Weight: 324.38

Compound Purity: 97.76

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: DNA/RNA Synthesis

• Artikelnummer: MEXHY-U00279-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-U00279-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK