Olaparib, CAS 763113-22-0

Product Description: Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

Applications: Cancer-programmed cell death

Formula: C24H23FN4O3

References: [1]Menear KA, et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51(20):6581-91/[2]Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17(3):272./[3]Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351./[4]Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10(10):1949-58.

CAS Number: 763113-22-0

Molecular Weight: 434.46

Compound Purity: 99.98

Research Area: Cancer

Solubility: DMF : 50 mg/mL (ultrasonic)/DMSO : 100 mg/mL (ultrasonic)/Ethanol : 3.12 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Autophagy;Mitophagy;PARP

• Artikelnummer: MEXHY-10162-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10162-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK