Orphenadrine, CAS 83-98-7

Product Description: Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and cytochrome P450 (CYP) 2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation[1][2][3].

Formula: C18H23NO

References: [1]Kornhuber J, et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46./[2]Pubill D, et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132(3):693-702./[3]Morita R, et al. Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress. J Toxicol Sci. 2013;38(3):403-13.

CAS Number: 83-98-7

Molecular Weight: 269.38

Compound Purity: 90

Research Area: Cancer; Neurological Disease

Solubility: 10 mM in DMSO

Target: Cholinesterase (ChE);Cytochrome P450;iGluR

• Artikelnummer: MEXHY-157959-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-157959-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK