Oxaprozin (Standard), CAS 21256-18-8

Product Description: Oxaprozin (Standard) is the analytical standard of Oxaprozin. This product is intended for research and analytical applications. Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].

Formula: C18H15NO3

References: [1]Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306./[2]Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785.

CAS Number: 21256-18-8

Molecular Weight: 293.32

Research Area: Inflammation/Immunology; Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: Akt;Apoptosis;COX;IKK;NF-κB

• Artikelnummer: MEXHY-B0808R-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0808R-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK