Product Description: PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS). PapRIV can cross the blood-brain barrier[1].
Formula: C38H53N9O13
References: [1]Janssens Y, et al. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci Rep. 2021 May 21;11(1):10723.
Molecular Weight: 843.88
Research Area: Inflammation/Immunology; Neurological Disease