PBT434, CAS 1232841-78-9

Product Description: PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD)[1].

Formula: C12H14BrCl2N3O2

References: [1]Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5(1):53./[2]Bailey DK, Clark W, Kosman DJ. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16(7):e0254794.

CAS Number: 1232841-78-9

Molecular Weight: 383.07

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: α-synuclein

• Artikelnummer: MEXHY-120475-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-120475-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK