PD-L1-IN-3, CAS 2953044-29-4

Product Description: PD-L1-IN-3 (Compound 4a) is a compound that targets PD-1/PD-L1, the IC50 value and EC50 value is 4.97nM and 2.70 μM for inhibit PD-L1 and Jurkat T cells, respectively. PD-L1-IN-3 can bind PD-L1 dimer to prevent PD-1 binding to PD-L1, therefore blocking PD-1 signaling. PD-L1-IN-3 can be used for lung cancer and melanoma diseases research[1].

Applications: Cancer-programmed cell death

Formula: C19H16ClFN2OS

References: [1]Ważyńska MA, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023 Jul 27;66(14):9577-9591.

CAS Number: 2953044-29-4

Molecular Weight: 374.86

Compound Purity: 99.52

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: PD-1/PD-L1

• Artikelnummer: MEXHY-155101-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-155101-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK