Pentabromophenol, CAS 608-71-9

Product Description: Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs)[1][2].

Formula: C6HBr5O

References: [1]Chen CL, et al. Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Sci Rep. 2017;7:43206. Published 2017 Feb 23./[2]Barańska A, et al. Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells. Molecules. 2022 Aug 9;27(16):5056.

CAS Number: 608-71-9

Molecular Weight: 488.59

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;TGF-beta/Smad

• Artikelnummer: MEXHY-W105318-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W105318-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK