Product Description: PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent PI3K/Akt/mTOR and tubulin polymerization inhibitor. PI3K/Akt/mTOR-IN-4 induce apoptosis and cell cycle arrest at G2/M phase. PI3K/Akt/mTOR-IN-4 decreases the expression of p-PI3K, p-Akt, and p-mTOR, β-tubulin[1].
Formula: C29H29FN4O3
References: [1]Li SS, et al. Design, synthesis, and biological evaluation of novel benzimidazole derivatives as anti-cervical cancer agents through PI3K/Akt/mTOR pathway and tubulin inhibition. Eur J Med Chem. 2024 Apr 16;271:116425.
Molecular Weight: 500.56
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Akt;Apoptosis;Microtubule/Tubulin;mTOR;PI3K